BVT

Odelis CPSE

Odelis CPSE picture

ELISA kit for the measurement of CPSE

Presentation Advantages

Method: ELISA type immunoassay on microwell

Analysis: CPSE assay (Canine Prostate-Specific arginine Esterase) on canine serum or plasma

Sample: plasma, serum

Handling time: 2 hours

Reading: 10 minutes

Presentation: Box set containing 1 microplate of 96 wells + reagents

Storage: 18 months at 2°C – 8°C

Performances:
Intra-test CV: less than 3.1%
Inter-test CV: less than 6.6%
Sensitivity: 0.39 ng/ml

For the diagnosis of Benign Prostatic Hyperplasia
(Threshold: 61 ng/ml)
Sensitivity: 97.1%; Specificity: 92.7%

Odelis CPSETM enables medical analysis laboratories to perform a quantitative assay of CPSE from a standard serum or plasma sample.

In the dog, the blood concentration of CPSE (Canine Prostate-Specific Esterase) increases in the presence of Benign Prostatic Hyperplasia.

Odelis CPSETM provides the practitioner with a simple and objective complementary examination to detect subclinical prostatic disease, and assess the necessity for instigating appropriate treatment.

Why use Odelis CPSE TM ?

Benign Prostatic Hyperplasia in the dog: a common disease with serious consequences

With age, and under the effect of impregnation with male hormones, the prostate of dogs is prone to the development of spontaneous diseases. The most commonly encountered disease is Benign Prostatic Hyperplasia or BPH, which corresponds to an increase in the number and size of the cells of the organ. Some dogs may present early histological lesions from as young as 5 years of age. (2)

The increase in the size of the prostate is progressive and continuous. An excessively large prostate can cause compression of the surrounding pelvic organs and the onset of painful and uncomfortable symptoms for the animal: constipation, tenesmus, dysuria, haematuria, lameness (compression of the intra-pelvic nerve roots)… (3)

Benign prostatic hyperplasia in the dog can predispose the animal to more serious diseases such as prostatitis, the appearance of voluminous prostatic cysts, or prostatic abscesses. (4)

CPSE (Canine Prostate-Specific arginine Esterase), a specific marker for BPH

CPSE is a hormone that is secreted by the prostate cells, under the control of androgens. This protein is a normal component of sperm (representing more than 90% of the proteins in the prostatic fluid).

Hyperplasia of the prostatic cells induces an increase in the serum concentration of CPSE(5).

When use Odelis CPSE TM ?

Odelis CPSETM provides the practitioner with a rapid means of evaluating the blood CPSE concentration in the dog, and helps them to confirm or eliminate a diagnosis of prostatic hyperplasia so that they can rapidly instigate appropriate treatment.

In dogs over 5 years of age, a CPSE assay provides an early and simple means of detecting Benign Prostatic Hyperplasia, from the earliest stages.

Odelis CPSETM is a simple and reliable alternative to rectal examination, which is often poorly tolerated by the animal and their owner.

Odelis CPSETM enables the practitioner to justify the performance of additional examinations to eliminate the possibility of concurrent disease (cysts, abscess, prostatitis, etc.)

Instruction for use Odelis CPSE TM

Odelis_CPSE_300.jpg

Bibliography:

(1) Lévy X., Mimouni P., Fontbonne A., Derre G., Claret E.,Audhuy S., Morlet J.Performance evaluation of the new blood test Odelis CPSETM in the diagnosis of Benign Prostatic Hyperplasia (BPH) in dogs. In. Prodeeding of the 6th EVSSAR Annual Symposium, Wroclaw 2009 - Poland
(2) Barsanti J. Canine prostatic disease. in Proceedings of the International SCIVAC Congress, Rimini 2008- Italy
(3) Vesrtegen J. Managment of prostatic disorders . In : Proceedings of the International WSAVA Congress, Granada 2002- Spain
(4) Johnston SD, Kustritz MVR, Olson PNS. Benign prostatic hypertrophy/hyperplasia. In : Canine and feline theriogenology. WB Saunders, Philadelphia. 2001 : 340-341
(5) Bell FW, Klausner JS, Hayden DW et coll. Evaluation of serum and seminal plasma markers in the diagnosis of canine prostatic disorders. J Vet Intern Med. 1995 ; 9 ; 149-153